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US 12,428,391 B2Granted
Dimethylsulfoximine derivative
AssigneeCisen Pharmaceutical Co., Ltd.
InventorsWenyuan Qian, Yonggang Liao, Changqing Wei, Zhengying Xi, Yao Xiao, Shuhui Chen
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Abstract
Disclosed in the present invention is a series of dimethylsulfoximine derivatives, and specifically disclosed are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.
Claims20
A compound represented by formula (II) or a pharmaceutically acceptable salt thereof,
- wherein, X is selected from O and NRb;
- R1 and R4 are each independently selected from H, C1-3 alkyl, phenyl and 5- to 6-membered heteroaryl, and the C1-3 alkyl, phenyl and 5- to 6-membered heteroaryl are optionally substituted with 1, 2 or 3 Ra;
- R2 and R3 are each independently selected from H, NH2, halogen and C1-3 alkyl;
- or R1 and R2 together with the carbon atoms to which they are attached form C4-5 cycloalkyl or C4-5 cycloalkenyl;
- or R3 and R4 together with the carbon atoms to which they are attached form C4-5 cycloalkyl or C4-5 cycloalkenyl;
- R5 is selected from H, F, Cl, D and CN;
- Ra is each independently selected from H, C1-3 alkoxy and CN;
- Rb is selected from H, CN and C1-3 alkyl;
- ring A is selected from 5-membered heteroaryl;
- the 5- to 6-membered heteroaryl and 5-membered heteroaryl contain 1, 2, 3 or 4 heteroatoms or heteroatom groups independently selected from —NH—, —O—, —S— and N.
7 more elements
A compound represented by the following formula or a pharmaceutically acceptable salt thereof, selected from:
Dependencies are inferred from the claim text.