Method for producing compound
AssigneeKureha Corporation
InventorsRyo Harigae, Chiemi Kojima, Shingo Konno, Toru Yamazaki
Life of this patent
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Abstract
A method by which an intermediate product of an azole derivative can be produced at a lower cost than known production methods is provided. A method for producing a compound represented by General Formula (IV) includes converting a compound represented by General Formula (II) into the compound represented by General Formula (IV) using (a) dimethyl sulfide and/or dimethyl sulfoxide, and (b) a methyl-LG (an LG is a nucleophilically substitutable leaving group and is selected from the group consisting of a halogen group, an alkoxysulfonyloxy group, an aryloxysulfonyloxy group, an alkylsulfonyloxy group, a haloalkylsulfonyloxy group, and an arylsulfonyloxy group) in the presence of an inorganic base.
Claims5
A method for producing a compound represented by General Formula (IV):
- where in General Formula (IV), R1 is a C1-C6-alkyl group;
- X1 is a halogen group, a C1-C4-haloalkyl group, or a C1-C4-haloalkoxy group;
- X2 is a halogen group, a C1-C4-haloalkyl group, or a C1-C4-haloalkoxy group;
- and
- n is 1, 2, or 3;
- the method comprising converting a compound represented by General Formula (III) into a compound represented by General Formula (II):
- where in Formula (II), R1, X1, X2, and n are respectively the same as R1, X1, X2 and n in Formula (IV),
- where in Formula (III), X1, X2, and n are respectively the same as X1, X2, and n in Formula (IV),
- wherein, in the converting step, in a solvent containing dimethyl sulfoxide, bromine is allowed to react with the compound represented by General Formula (III) while a reaction system is heated, and subsequently R1—OH (where R1 is the same as R1 in Formula (IV)) is allowed to react, and thus the compound represented by General Formula (II) is formed,
- wherein the step of converting into the compound represented by General Formula (II) is performed in the presence of at least one selected from the group consisting of urea, adipic acid dihydrazide, and dibutylhydroxytoluene,
- the method further comprising converting thea compound represented by General Formula (II) into the compound represented by General Formula (IV) using:
- (a) dimethyl sulfide and/or dimethyl sulfoxide, and
- (b) a methyl-LG, where LG is a nucleophilically substitutable leaving group and is selected from the group consisting of a halogen group, an alkoxysulfonyloxy group, an aryloxysulfonyloxy group, an alkylsulfonyloxy group, a haloalkylsulfonyloxy group, and an arylsulfonyloxy group
- in the presence of an inorganic base.
Dependencies are inferred from the claim text.