Bioactive smart scaffolds for regenerative medicine
AssigneeUniversity of Cincinnati
InventorsLeyla Esfandiari, Gregory Harris
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Abstract
Provided herein are implantable biomaterials for promoting regeneration of an injured biological tissue, the biomaterials including piezoelectric materials and an extracellular matrix specific to the injured biological tissue, wherein the piezoelectric materials and the extracellular matrix are electrospun together to provide tissue-specific bioactive piezoelectric nanofiber scaffolds. Also provided herein are methods of fabricating a tissue-specific bioactive piezoelectric nanofiber scaffold and methods of promoting regeneration of injured biological tissue by implanting the disclosed bioactive piezoelectric scaffolds.
Claims23
An implantable biomaterial for promoting regeneration of an injured biological tissue, the biomaterial comprising:
- a piezoelectric material comprising a polyvinylidene fluoride (PVDF) copolymer;
- and
- a decellularized extracellular matrix specific to the injured biological tissue,
- wherein the piezoelectric material and the decellularized extracellular matrix are electrospun together to provide a tissue-specific bioactive piezoelectric nanofiber scaffold, and
- wherein the electrospun piezoelectric nanofibers of the scaffold are substantially uniaxially aligned.
A method for fabricating a biomaterial for regeneration of an injured biological tissue, the method comprising:
- providing a hybrid solution comprising:
- a piezoelectric material comprising a polyvinylidene fluoride (PVDF) copolymer;
- and
- a decellularized extracellular matrix specific to the injured biological tissue;
- electrospinning the hybrid solution to provide a tissue-specific bioactive piezoelectric nanofiber scaffold,
- wherein the electrospun piezoelectric nanofibers of the scaffold are substantially uniaxially aligned.
A method of promoting regeneration of injured biological tissue in a patient in need thereof, the method comprising:
- providing a tissue-specific bioactive piezoelectric nanofiber scaffold comprising a piezoelectric material comprising a polyvinylidene fluoride (PVDF) copolymer and a decellularized extracellular matrix specific to the injured biological tissue of the patient, wherein the piezoelectric material and the decellularized extracellular matrix are electrospun together to form substantially uniaxially aligned nanofibers;
- and
- implanting the tissue-specific bioactive piezoelectric nanofiber scaffold at a site of the injured biological tissue of the patient,
- wherein the tissue-specific bioactive piezoelectric nanofiber scaffold delivers one or more stimuli to the site of the injured biological tissue that promote regeneration of the injured biological tissue.
Dependencies are inferred from the claim text.