Iodinated phenolic lipids and methods and cosolvent systems for iodination of phenolic lipids
AssigneesUniversity of Cincinnati, Molecular Targeting Technologies, Inc.
InventorsXiaoyang Qi, Koon Yan Pak, Brian D. Gray
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Abstract
Compositions that include a phenol group conjugated to a lipid group to form a phenolic lipid. The lipid group may include a fluorophore and at least one lipid anchor. The lipid anchor may have a carbon number that ranges between 7 carbon atoms and 22 carbon atoms. Also, included are methods of making and using such phenolic lipids. Further included are methods of iodinating hydrophobic compounds such as phenolic lipids in aqueous based iodination protocols. Cosolvent formulations for use in such methods are also described.
Claims6
A composition comprising a phenol group conjugated to a lipid group, wherein the lipid group includes a lipid portion coupled to a fluorophore, and wherein the lipid group is selected from the group consisting of DilC22, DilC14,22, and combinations thereof.
A composition comprising:
- a phenolic lipid and at least one of a vesicle or a micelle,
- wherein the phenolic lipid includes a lipid group conjugated to a phenol group and the lipid group includes a lipid portion coupled to a fluorophore, and wherein the lipid group is selected from the group consisting of DilC22, DilC14,22, and combinations thereof.
Dependencies are inferred from the claim text.