Pharmaceutical formulations
AssigneesBlue Earth Diagnostics Limited, Siemens Medical Solutions USA, Inc.
InventorsRomain Bejot, Michael Haka, Atilio Anzellotti
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Abstract
The present invention relates to a pharmaceutical composition comprising a radiohybrid agent containing a silicon-fluoride and a chelating group wherein either the fluorine is 18F or the chelating group contains a chelated radioactive metal, wherein the composition has a ph of 4.0-6.0 and further comprises: 0.1-200 mM citrate buffer; 1-100 mg/ml ethanol; and 5-10 mg/ml sodium chloride.
Claims8
A pharmaceutical composition comprising a radiohybrid agent containing a silicon-fluoride group and a chelating group, wherein either the fluorine of the silicon-fluoride group is 18F or the chelating group contains a chelated radioactive metal, wherein the radiohybrid agent is:
- or an isomer or salt thereof, wherein M3+is a chelated radioactive or non-radioactive metal, and
- wherein the composition has a pH of 4.0-6.0 and further comprises 0.1-200 mM citrate buffer.
Dependencies are inferred from the claim text.