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US 12,427,206 B2Granted
Method of assessing regulation of an immune response to an administered agent by measuring activation of nodose ganglion neurons
AssigneeThe Trustees of Columbia University in the City of New York
InventorsCharles S. Zuker, Hao Jin
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Abstract
Disclosed herein are methods for regulating an immune response using selective activation of neurons in the caudal nucleus of the solitary tract.
Claims15
A method of assessing the ability of a therapeutic agent to regulate an immune response, comprising
- administering the therapeutic agent to a subject;
- measuring in the subject, in response to the therapeutic agent:
- a) activation of nodose ganglion neurons which are activated by pro-inflammatory cytokines;
- and
- b) activation of nodose ganglion neurons which are activated by anti-inflammatory cytokines;
- and
- comparing the activation by the therapeutic agent of nodose ganglion neurons which are activated by pro-inflammatory cytokines to the activation by the therapeutic agent of nodose ganglion neurons which are activated by anti-inflammatory cytokines.
4 more elements
A method of assessing an alteration of an immune response in a subject, the method comprising:
- administering a small molecule compound to the subject;
- measuring in the subject, in response to the small molecule compound:
- a) activation of a neuronal subset of nodose ganglion neurons activated by pro-inflammatory cytokines;
- and
- b) activation of a neuronal subset of nodose ganglion neurons activated by anti-inflammatory cytokines;
- and
- comparing the activation of the neuronal subset activated by pro-inflammatory cytokines to the activation of the neuronal subset activated by anti-inflammatory cytokines.
4 more elements
Dependencies are inferred from the claim text.