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US 12,427,203 B2Granted
Long acting multi-specific molecules and related methods
AssigneeShenzhen Enduring Biotech, Ltd.
InventorsShu-min Liu, Dechun Wu
Life of this patent
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Abstract
This invention relates to multi-specific molecules, such as long acting multi-specific antibodies. Also disclosed are related methods.
Claims14
A compound of the Formula Ib:
- wherein:
- P is a polyethylene glycol (PEG);
- B is H, a terminal capping group or void, said capping group selected from C1-50 alkyl and aryl, wherein one or more carbons of said alkyl may be replaced with a heteroatom;
- T is a tri-functional linker, wherein the linkage between T and (L1)a and the linkage between T and (L2)b are the same or different;
- wherein said linkage between T and (L1)a or T and (L2)b is derived from hydroxyl, amino, hydrazinyl, carboxyl, thiol, halide, alkene, anhydride, or maleimide;
- or combinations thereof;
- each of L1 and L2 is independently a bifunctional linker;
- a and b are each an integer selected from 1 to 10;
- one of A1 and A2 is a protein encoded by SCACD3 (SEQ ID No:
- 3) and the other is a protein encoded by SCACD19 (SEQ ID No. 4);
- and
- y is 1.
9 more elements
Dependencies are inferred from the claim text.