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US 12,427,192 B2Granted
Water soluble adjuvant and composition containing same
AssigneeSumitomo Pharma Co., Ltd.
InventorsHitoshi Ban, Yosuke Takanashi, Masashi Goto, Natsuko Suginobe, Yusuke Imazaki, Yoshiko Iwata
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Abstract
The present invention relates to a compound useful as a vaccine adjuvant for cancer vaccine, a preparation process thereof, a pharmaceutical composition comprising the compound, and use of the compound as a vaccine adjuvant for cancer vaccine.
Claims39
A compound of formula (1):
- or a pharmaceutically acceptable salt thereof, wherein
- X is methylene, oxygen atom, sulfur atom, SO, SO2, or NR5, wherein R5 is hydrogen or C1-6 alkyl,
- R1 is C1-6 alkyl which is optionally substituted with 1-5 substituents selected independently from the group consisting of halogen, hydroxy, and C1-6 alkoxy,
- R2 and R3 are independently hydrogen or C1-6 alkyl which is optionally substituted with 1-5 substituents selected independently from the group consisting of halogen, hydroxy, and C1-6 alkoxy,
- R4 is hydrogen, halogen, hydroxy, C1-6 alkyl, which is optionally substituted with 1-3 the same or different halogens, C1-6 alkoxy, which is optionally substituted with 1-3 the same or different halogens, or cyano,
- L is a linker, and
- Y1 is —(CH2CH2O)m—R6, wherein R6 is hydrogen or C1-6 alkyl, and m is an integer from 3-100.
4 more elements
Dependencies are inferred from the claim text.