Fecal fungome and therapeutic efficacy of fecal microbiota transplantation
AssigneeThe Chinese University of Hong Kong
InventorsSiew Chien Ng, Tao Zuo, Ka Leung Francis Chan
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Abstract
The present invention resides in the discovery that altered abundance of fungal species in the gut and feces of both fecal microbiota transplantation (FMT) donors and recipients may influence the outcome of FMT treatment. Thus, novel methods are provided for identifying subjects as suitable donor or recipients for FMT, for assessing the likelihood of FMT treatment success, and for enhancing FMT treatment efficacy. Also provided are kits and compositions for FMT with enhanced efficacy.
Claims15
A method for treating Clostridium difficile infection (CDI) by fecal microbiota transplantation (FMT), comprising the steps of:
- (i) identifying a donor candidate for FMT for treating CDI as a suitable donor upon determining Candida albicans level in a stool sample obtained from the candidate as no greater than 0.1% in relative abundance in the stool sample;
- and
- (ii) performing FMT by administering a composition comprising stool from the suitable donor identified in step (i) to a recipient having CDI to achieve resolution of diarrhea and negative Clostridium difficile toxin in the recipient's stool.
Dependencies are inferred from the claim text.