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US 12,427,127 B2Granted
Carmustine formulation
AssigneeEmcure Pharmaceuticals Limited
InventorsDeepak Pragjibhai Gondaliya, Hiren Pravinbhai Patel, Haresh Ishwarbhai Patel, Mukund Keshav Gurjar
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Abstract
The present invention relates to a composition comprising nitrosourea and pharmaceutically acceptable excipients. In particular, the present invention relates to novel drug delivery systems of carmustine such as nano-suspension and micro-emulsion and its use for the treatment of cancer by intravenous administration. Also provided are methods for preparation of such novel drug delivery systems.
Claims5
A drug composition comprising:
- (i) 0.1 wt % to 50 wt % of carmustine:
- (ii) 1 wt % to 70 wt % of a combination of phosphatidylcholine and sodium cholesteryl sulfate:
- (iii) 1 wt % to 60 wt % of poly (lactic-co-glycolic acid) (PLGA):
- (iv) sucrose and (v) water wherein the ratio of carmustine to PLGA ranges from 1:3 to 1:6 weight-per-weight (w/w) and the composition is a nano-suspension.
1 more element
Dependencies are inferred from the claim text.