Phenylalanine-based LAT1 inhibitors and uses thereof

A compound having the structure of Formula (3):

• or a pharmaceutically acceptable salt thereof, wherein,
• R6 is selected from —COOH, —COORa, —CORa, and —CON(Rb)2, wherein,
• Ra is C1-4 alkyl;
• and
• each Rb is independently selected from hydrogen, —OH, C1-4 alkyl, and C1-4 alkoxy;
• R7 is selected from hydrogen and methyl;
• R8 is selected from hydrogen, halogen, C1-3 alkyl, and C1-3 alkoxy;
• R9 is selected from —S(O)2—NR— and —NR—S(O)2—, wherein R is selected from hydrogen and methyl;
• R10 is selected from C6-10 aryl, substituted C6-10 aryl, C5-6 cycloalkyl, and biphenyl;
• and
• each substituent is independently selected from halogen, phenyl, —N(—R)2, C1-4 alkoxy, and C1-4 alkyl, wherein each R is independently selected from hydrogen and methyl.