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US 12,427,109 B2Granted
Natural origin stabilizer for oil in water emulsions
AssigneeFundacióN Cidetec
InventorsMarcos Navascuez Lominchar, Iraida Loinaz Bordonabe, Damien Dupin, Jordi Llop Roig, Fernando López-Gallego
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Abstract
The present invention relates to the use of a methacrylate or acrylate modified polysaccharide; or a single-chain polysaccharide methacrylate or acrylate-based nanoparticle, having a surface tension measured by Du Noüy Ring method equal to or lower than 63 mN/m, as oil-in-water emulsion stabilizer; and an oil-in-water emulsion stabilizer composition, and an oil-in-water emulsion containing them. It also relates to processes for their preparation, and their uses.
Claims18
An oil-in-water emulsion comprising:
- (a) an external water phase (W) comprising:
- (a1) a solvent selected from the group consisting of water, glycol, and a mixture thereof;
- and
- (a2) optionally, one or more hydrophilic compounds selected from the group consisting of:
- (a2′) hydrophilic active agent and (a2″) hydrophilic excipients or carriers;
- (b) the internal oily phase (O) comprising one or more lipophilic compounds selected from the group consisting of:
- (b1) lipophilic active agents, and
- (b2) lipophilic excipients or carriers;
- and
- (c) an interfacial layer (IL) between the external water phase (W) and the internal oily phase (O) comprising:
- (c1) one or more emulsion stabilizer selected from the group consisting of:
- (c1′) methacrylate or acrylate modified polysaccharides having a surface tension measured by Du Noüy Ring method equal to or lower than 63 mN/m;
- (c1″) single-chain polysaccharide methacrylate or acrylate-based nanoparticles having a surface tension measured by Du Noüy Ring method equal to or lower than 63 mN/m;
- (c1′″) interfacial crosslinked methacrylate or acrylate modified polysaccharides obtainable by reacting the methacrylate or acrylate modified polysaccharides as defined in (c1′) with an interfacial crosslinking agent, wherein the interfacial crosslinked methacrylate or acrylate modified polysaccharides has an interfacial crosslinking degree from 25 to 100% of the methacrylate or acrylate groups of the polysaccharide;
- or alternatively,
- (c1″″) interfacial crosslinked single-chain polysaccharide methacrylate or acrylate based nanoparticles obtainable by reacting the single-chain polysaccharide methacrylate or acrylate-based nanoparticles as defined in (c1″) with an interfacial crosslinking agent, wherein the interfacial crosslinked single-chain polysaccharide methacrylate or acrylate based nanoparticles has an interfacial crosslinking degree from 25 to 100% of the methacrylate or acrylate groups of the nanoparticles;
- wherein the carbon atom of the group —CO— of the methacrylate or acrylate moiety is covalently bonded to the oxygen atom of the OH— moiety of the polysaccharide;
- and
- c2) optionally, one or more hydrophilic active agents.
16 more elements
Dependencies are inferred from the claim text.