US 12,427,105 B2 · Hydrogel-based biological delivery vehicle

Abstract

A hydrogel-based biological delivery vehicle used to effectively deliver drug and biological material to tissue or organ sites. More specifically, a hydrogel binding matrix having a biopolymer backbone containing carboxyl groups. Tyramine may be substituted for at least a portion of the carboxyl groups, so that, when hydrogen peroxide is added, it causes creation of covalent bonds between tyramine molecules and cross-links the hydrogel binding matrix, thereby enabling the hydrogel binding matrix to transition from liquid to gel state. The hydrogel binding matrix, in its liquid form, is capable of encapsulating drug reservoirs to create a homogenous liquid with evenly distributed particles containing drugs or target molecules. As the hydrogel binding matrix solidifies into a gel state, the newly created cross-links do not disrupt or react with the drugs or target molecules contained within the drug reservoirs. This hydrogel-based biological delivery vehicle can be used in several medical applications.

Claims18

Dependent claims

A hydrogel-based drug delivery vehicle for delivering a drug to a wound comprising:

a) a first hydrogel matrix comprising a solvent and a plurality of chains of a first biopolymer dissolved in the solvent, the first biopolymer having a structure:
wherein n is an integer greater than or equal to 220;
wherein R is COOH or tyramine and wherein from 0.5 mol % to 3.0 mol % of R of the first biopolymer is tyramine;
and
wherein the solvent is water;
and
b) a plurality of drug reservoirs dispersed throughout the first hydrogel matrix;
and
c) a cross-linking agent, wherein the cross-linking agent cross links tyramines within the first hydrogel matrix.

6 more elements

Dependencies are inferred from the claim text.

Hydrogel-based biological delivery vehicle

Life of this patent

Hydrogel-based biological delivery vehicle

Life of this patent

Abstract

Claims18