Method for manufacturing bone graft substitute having holes

A method of manufacturing a bone grafting substitute having a hole, the method comprising:

• preparing biodegradable polymer;
• preparing a molding material by mixing the biodegradable polymer with a bone material;
• injecting the molding material into a hole forming mold for molding a bone grafting substitute having a hole;
• and
• drying the molding material injected into the hole forming mold at a predetermined temperature,
• wherein the biodegradable polymer is collagen, the collagen comprises porcine ligament-derived collagen, and preparing the collagen comprises:
• pretreating porcine ligament to obtain collagen from the porcine ligament;
• forming the pretreated porcine ligament into collagen dough;
• mixing the collagen dough with an alcohol aqueous solution into a homogenized collagen solution;
• and
• filtering collagen from the homogenized collagen solution.