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US 12,424,427 B2Granted
Two dimensional MSMS
AssigneeMicromass UK Limited
InventorsKeith Richardson, Jason Lee Wildgoose
Life of this patent
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Abstract
A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.
Claims20
A method of mass spectrometry comprising:
- performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises:
- mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses capable of being transmitted therefrom is varied with time;
- and
- mass analysing ions;
- wherein ions transmitted by the mass separator or filter in at least some of said cycles are fragmented or reacted to produce fragment or product ions, and wherein the method comprises varying the fragmentation energy or rate, or reaction energy or rate, during one or more of said cycles, or during said experimental run.
2 more elements
A mass spectrometer comprising:
- a mass separator or mass filter;
- a mass analyser;
- and
- a controller arranged and adapted to control the spectrometer to perform a plurality of cycles of operation during a single experimental run, wherein each cycle comprises:
- mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of the mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses capable of being transmitted therefrom is varied with time;
- and
- mass analysing ions in the mass analyser;
- wherein ions transmitted by the mass separator or filter in at least some of said cycles are fragmented or reacted to produce fragment or product ions, and the fragmentation energy or rate, or reaction energy or rate, is varied during one or more of said cycles, or during said experimental run.
5 more elements
Dependencies are inferred from the claim text.