Antibodies that bind to natively folded myocilin
AssigneeGeorgia Tech Research Corporation
InventorsRaquel L. Lieberman, Shannon E. Hill, Athena Patterson-Orazem, Jennifer A. Maynard, Ahlam Qerqez, Laura Azouz Yuan
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Abstract
Myocilin-binding agents including antibodies and antigen binding fragments thereof and fusion proteins that immunospecifically bind the coiled-coil domain of myocilin but do not bind to misfolded myocilin are provided herein. The disclosed antibodies and antigen binding fragments and fusion proteins are useful for the detection and extraction of natively folded myocilin from a sample.
Claims18
An antibody or antigen-binding fragment thereof that specifically binds to natively folded myocilin but does not bind to misfolded myocilin;
- wherein the antibody comprises:
- a HCDR1 domain having the amino acid sequence according to SEQ ID NO:12;
- a HCDR2 domain having the amino acid sequence according to SEQ ID NO:13;
- a HCDR3 domain having the amino acid sequence FVY;
- a LCDR1 domain having the amino acid sequence according to SEQ ID NO:9;
- a LCDR2 domain having the amino acid sequence according to SEQ ID NO:10;
- and
- a LCDR3 domain having the amino acid sequence according to SEQ ID NO:11.
An antibody or antigen-binding fragment thereof that specifically binds to natively folded myocilin, wherein the antibody comprises:
- a HCDR1 domain having the amino acid sequence according to SEQ ID NO:12;
- a HCDR2 domain having the amino acid sequence according to SEQ ID NO:
- 18;
- a HCDR3 domain having the amino acid sequence FVY;
- a LCDR1 domain having the amino acid sequence according to SEQ ID NO:9;
- a LCDR2 domain having the amino acid sequence according to SEQ ID NO:10;
- and
- a LCDR3 domain having the amino acid sequence according to SEQ ID NO:11.
Dependencies are inferred from the claim text.