Devices and methods including a preconcentrator material for detection of analytes
AssigneeMassachusetts Institute of Technology
InventorsTimothy Manning Swager, Jisun Im, Alexander Robertson Petty, Jan Markus Schnorr, Cindy Schmädicke
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Abstract
Embodiments described herein provide devices and methods for the determination of analytes. The device typically includes an absorbent material that allows for an analyte sample to be concentrated and analyzed simultaneously and within a short period of time (e.g., less than 10 seconds). Embodiments described herein can provide portable and easily operable devices for on-site, real time field monitoring with high sensitivity, selectivity, and fast response time.
Claims21
A device for determining an analyte, comprising:
- a sensor material layer comprising a conductive material comprising carbon nanotubes;
- and
- an absorbent material layer disposed on the sensor material layer,
- wherein the absorbent material interacts with an analyte, if present, in a manner bringing the analyte into proximity with the sensor material layer to produce a determinable signal from the device,
- wherein the absorbent material layer comprises a functionalized cellulose-based polymer and/or an iptycene-based polymer,
- wherein the absorbent material layer acts as a preconcentrator for the analyte, and
- wherein the absorbent material layer optionally comprises an ionic liquid,
- wherein the cellulose-based polymer comprises the structure,
- wherein R2 and R3 can be the same or different and are hydrogen, alkyl, aryl, a carbonyl group, any of which is optionally substituted,
- wherein R4 and R5 can be the same or different and are hydrogen, alkyl, alkenyl, aryl, heteroalkyl, heteroalkenyl, heteroaryl, or carbonyl group, any of which is optionally substituted,
- wherein R6 is alkyl, alkenyl, aryl, heteroalkyl, heteroalkenyl, or heteroaryl, any of which is optionally substituted, and
- wherein n is greater than 1.
A device for determining an analyte, comprising:
- a first electrode and a second electrode;
- a sensor material in electrochemical communication with the first and the second electrodes, wherein resistance to current flow between the first and second electrode is affected by the sensor material;
- and
- an absorbent material in contact with and disposed on the sensor material,
- wherein the absorbent material layer comprises a functionalized cellulose-based polymer and/or an iptycene-based polymer,
- wherein the absorbent material optionally comprises an ionic liquid;
- wherein the absorbent material acts as a preconcentrator for the analyte;
- wherein the sensor material comprises a carbon nanotubes, and
- wherein the absorbent material interacts with the analyte, if present, in a manner bringing the analyte into proximity with the sensor material such that resistance to current flow between the first and second electrodes is affected, thereby generating a signal in the device by which the analyte is determined,
- wherein the cellulose-based polymer comprises the structure,
- wherein R2 and R3 can be the same or different and are hydrogen, alkyl, aryl, a carbonyl group, any of which is optionally substituted,
- wherein R4 and R5 can be the same or different and are hydrogen, alkyl, alkenyl, aryl, heteroalkyl, heteroalkenyl, heteroaryl, or carbonyl group, any of which is optionally substituted,
- wherein R6 is alkyl, alkenyl, aryl, heteroalkyl, heteroalkenyl, or heteroaryl, any of which is optionally substituted, and
- wherein n is greater than 1.
Dependencies are inferred from the claim text.