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AssigneesThe Broad Institute, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital Corporation
InventorsAviv Regev, Nir Hacohen, Vijay K. Kuchroo, Ana Carrizosa Anderson, Orit Rozenblatt-Rosen, Jonathan Chen, Karin Pelka, Matan Hofree
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The present invention is generally directed to a colorectal (CRC) cell atlas that provides methods of predicting outcomes of cancer patients and therapeutic targets for treating patients in need thereof. The atlas may be used to predict a response to immunotherapy, in particular checkpoint blockade therapy and adoptive cell transfer. Disclosed herein are previously unidentified gene programs in tumors that can be used to predict response and provide for therapeutic targets that can be used to shift a tumor to a responsive phenotype.
An engineered T cell comprising:
Dependencies are inferred from the claim text.