Methods and compositions for treating hyperoxaluria
AssigneeTenza, Inc.
InventorsZachary Nicholas Russ, IV, Weston Robert Whitaker, William Cain DeLoache, Elizabeth Joy Stanley Shepherd
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Abstract
The disclosure relates generally to bacteria that have been modified to have increased oxalate degrading activity, pharmaceutical compositions including the bacteria, and methods of treating disorders associated with an elevated amount of oxalate, e.g., hyperoxaluria.
Claims13
A commensal bacterium comprising one or more transgenes encoding a protein that increases the oxalate degrading activity of the bacterium relative to an unmodified bacterium and increases the ability of the bacterium to utilize a privileged nutrient as a carbon source, wherein the bacterium comprises:
- (a) one or more transgenes encoding a S. cerevisiae OXS, a S. cerevisiae OXC, and an O. formigenes OxIT;
- (b) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, and an O. formigenes OxIT;
- (c) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an E. coli ACOCT, and an O. formigenes OxIT;
- (d) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an A. thaliana OXS, an E. coli ACOCT, and an O. formigenes OxIT;
- (e) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, an O. formigenes OxIT, an E. coli ACOCT, and a S. cerevisiae OXS;
- (f) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S. cerevisiae OXC, an E. coli ACOCT, a S. cerevisiae OXS, and an A. thaliana OXS;
- or
- (g) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S. cerevisiae OXC, an E. coli ACOCT, and a S. cerevisiae OXS.
Dependencies are inferred from the claim text.