Method of stimulating proliferation of a cell
AssigneeAgency for Science, Technology and Research
InventorsTorsten Wuestefeld, Viktoriia Iakovleva
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Abstract
Methods of treating and preventing diseases associated with fibrosis are disclosed, as well as agents for use in such methods. The methods comprise inhibiting at least one of ITFG1, MFAP4, GRHPR, ABCC4, PAK3, TRNP1, APLN, KIF20A, and/or LTB. In one embodiment, the disease is a liver disease or condition. Also disclosed are methods of promoting regeneration of cells, such as hepatocytes.
Claims16
A method of treating fibrosis in a disease characterised by fibrosis, comprising administering a therapeutically-effective amount of an inhibitory nucleic acid comprising or encoding antisense nucleic acid for inhibiting T-cell immunomodulatory protein (ITFG1) gene expression to a subject having the disease characterised by fibrosis, wherein the inhibitory nucleic acid is an siRNA, dsiRNA, shRNA or antisense oligonucleotide.
A method of inhibiting fibrosis of the liver in a subject, comprising administering to a subject in need thereof an inhibitory nucleic acid comprising or encoding antisense nucleic acid for inhibiting T-cell immunomodulatory protein (ITFG1) gene expression, wherein the inhibitory nucleic acid is an siRNA, dsiRNA, shRNA or antisense oligonucleotide.
Dependencies are inferred from the claim text.