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US 12,421,369 B2Granted
Porous polymer scaffolds, and methods of making and using the same
AssigneeThe Regents of the University of California
InventorsTejal A. Desai, Ryan Chang, Jasper Z. Williams
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Abstract
Polycaprolactone (PCL) scaffolds having macropores interconnected with micorpores are provided. Tissue grafts that include the PCL scaffold having therapeutic cells encapsulated within the macropores are also provided. Also provided are methods of making the PCL scaffold and the tissue graft, and methods of transplanting cells into an individual using the tissue graft.
Claims15
A polycaprolactone (PCL) scaffold consisting of:
- a monolithic, continuous structure comprising a plurality of pores, wherein the plurality of pores comprises macropores interconnected by struts containing micropores, wherein the macropores have an average diameter of from 50 μm to 500 μm and the micropores have an average diameter of 20 μm or less;
- and
- wells that are distinct from the plurality of pores and that are arranged on the surface of the scaffold in a honeycomb pattern;
- wherein the micropores and macropores are present on external surfaces of the PCL scaffold.
1 more element
Dependencies are inferred from the claim text.