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US 12,421,275 B2Granted
Compositions and methods for treating CNS disorders
AssigneeSage Therapeutics, Inc.
InventorsAlbert Jean Robichaud, Francesco G. Salituro, Maria Jesus Blanco-Pillado, Daniel La, Boyd L. Harrison
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Abstract
Provided herein is a compound of Formula (I-I) or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I-I), and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
Claims28
A compound of Formula (I-III)
- or a pharmaceutically acceptable salt thereof, wherein
- m is 0, 1, or 2;
- X is —O—;
- R3a is unsubstituted C1-6 alkyl or C1-6 alkyl substituted with C1-6 alkoxy;
- R5 is hydrogen or methyl;
- R1 is substituted or unsubstituted C1-6 alkyl or substituted or unsubstituted heteroaryl;
- and
- each of R1a, R1b, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, R12b, R15a, R15b, R16a, and R16b is hydrogen.
5 more elements
A compound selected from
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.