Polymer beads for oligonucleotide synthesis
AssigneeAgilent Technologies, Inc.
InventorsDouglas J. Dellinger, Logan Garner, John W. Davies, Thomas Jacob Cobb, Richard Bacon, David James Neep, Matthew Williamson
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Abstract
A resin formed of copolymer beads is disclosed. The copolymer beads have a first repeating motif, a second repeating motif having a substituted styrene with an ester functional group or an amide with a terminal amine or hydroxyl functional group, and a crosslinking agent having a divinyl compound. The copolymer beads are capable of expanding substantially uniformly in polar and non-polar solvents.
Claims18
A copolymer bead comprising a first repeating motif, a second repeating motif being a compound of one of formulas (II) or (III), and a crosslinking agent comprising a divinyl compound,
- wherein Q is NH2 or OH, n is an integer from 0 to 12, and p is an integer from 0 to 11;
- wherein Q is NH2 or OH, n is an integer from 0 to 12, p and r are integers each independently from 0 to 11, and q is an integer from 0 to 6.
A resin formed of copolymer beads comprising a first repeating motif, a second repeating motif having a substituted styrene with an ester functional group or an amide with a terminal amine or hydroxyl functional group, and a crosslinking agent comprising a divinyl compound, the copolymer beads being capable of expanding to a predetermined volume substantially uniformly in polar and non-polar solvents, the predetermined volume being from about 2 to about 3 times their dry volume.
Dependencies are inferred from the claim text.