Compositions and methods for inhibiting group II intron RNA
AssigneeYale University
InventorsAnna Marie Pyle, Olga Fedorova, Erik Jagdmann, Michael Van Zandt, Lin Yuan, Albert DeBerardinis
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Abstract
The present invention provides compositions and methods for inhibiting group II intron splicing for treating or preventing a disease or disorder associated with an organism harboring an active group II intron. The present invention also provides compositions and methods for inhibiting group II intron splicing for inhibiting, preventing or reducing growth of an organism harboring an active group II intron.
Claims5
A compound selected from the group consisting of:
- or a salt thereof.
A method of reducing, or preventing growth of an organism harboring an active group II intron, wherein the organism is selected from the group consisting of a bacteria, a yeast, a fungus, a protist, a parasite, and a plant,
- the method comprising contacting the organism with an effective amount of an inhibitor of group II intron splicing selected from the group consisting of:
- or a salt thereof.
A method of treating or ameliorating a disease associated with an organism harboring an active group II intron in a subject, wherein the disease or disorder is selected from the group consisting of a bacterial infection, a yeast infection, a fungal infection, and a parasite infection,
- the method comprising administering to the subject an effective amount of an inhibitor of group II intron splicing selected from the group consisting of:
- or a salt thereof.
Dependencies are inferred from the claim text.