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US 12,421,205 B2Granted
GLP-1 receptor agonist
AssigneeHyundai Pharm Co., Ltd.
InventorsHan Kyu Lee, Jeong-Un Hwang, Kyu-Hwan Lee, Hyung-Ho Choi, Jung-In Jang, Hyuck-Joo Lee, Seung-Tae Kang, Hyun-Ho Yoon, Neul Ha, Hyun-Hwa La, Jin Woong Kim, Dae Hoon Kim, Myoung Ki Baek
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Abstract
The present invention relates to a compound represented by Formula 1 wherein A, B, L, X, and R1 to R6 are as described herein, or a pharmaceutically acceptable salt thereof, which serves as a GLP-1 receptor agonist and may be useful in the prevention or treatment of a disease associated with GLP-1 activity.
Claims15
A compound represented by the following Formula 1, or a pharmaceutically acceptable salt thereof:
- wherein
- A is C6-10 aryl;
- C3-7 cycloalkyl;
- 5- or 6-membered heteroaryl containing one heteroatom selected from N, O, and S;
- 5- or 6-membered heterocycloalkyl containing one heteroatom selected from N, O, and S;
- or 9- or 10-membered fused heteroaryl containing at least one heteroatom selected from N, O, and S,
- B is any one of the following (1) to (5),
- L is —(CH2)n-O—, —O—(CH2)n-, —(CH2)n-NH—, —NH—(CH2)n-, —(CH2)n-N(C1-5 alkyl)-, —N(C1-5 alkyl)-(CH2)n-, —CONH—, or —NHCO—, where n is 1 or 2,
- X is CH or N,
- R1 and R2 are each independently selected from the group consisting of hydrogen, C1-5 alkyl, C1-5 alkoxy, C1-5 haloalkyl, halogen, cyano, and nitro,
- R3 is hydrogen or halogen,
- R4 and R5 are each independently selected from the group consisting of hydrogen, C1-5 alkyl, C1-5 alkoxy, C1-5 haloalkyl, halogen, cyano, and nitro,
- R6 is —(CH2)m—O—(C1-5 alkyl) (where m is 1 or 2);
- C1-5 haloalkyl;
- 5- or 6-membered heteroaryl containing one or two heteroatoms selected from N, O, and S, which is unsubstituted or substituted with C1-5 alkyl;
- or 4- or 5-membered heterocycloalkyl containing one heteroatom selected from N, O, and S, which is unsubstituted or substituted with C1-5 alkyl.
13 more elements
Dependencies are inferred from the claim text.