Modified amino acid derivatives for the treatment of neurological diseases and selected psychiatric disorders
AssigneesUniwersytet Jagiellonski, Warszawski Uniwersytet Medyczny
InventorsKrzysztof Kaminski, Michal Abram, Marcin Jakubiec, Anna Rapacz, Szczepan Mogilski, Gniewomir Latacz, Marta Struga
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Abstract
2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2-oxopyrrolidin-1-yl)propanamide derivatives with R-configuration at the stereogenic center are disclosed, showing broad-spectrum protective activity in animal models of epileptic seizures, pain, depression and anxiety that are simultaneously devoid of undesirable sedative effects. Additionally, the disclosed derivatives have neuroprotective effects in the in vitro and in vivo studies.
Claims51
A method of treating a neurological disorder, wherein the method comprises administering to an animal a compound of formula (I):
- wherein:
- X is hydrogen or N(CH3)2,
- Y is CH2 or C═O,
- R is hydrogen or halogen,
- or a pharmaceutically acceptable salt thereof.
A method of treating a psychiatric disorder, wherein the method comprises administering to an animal a compound of formula (I):
- wherein:
- X is hydrogen or N (CH3)2,
- Y is CH2 or C═O,
- R is hydrogen or halogen,
- or a pharmaceutically acceptable salt thereof.
A method of treating inflammatory pain, wherein the method comprises administering to an animal a compound of formula (I):
- wherein:
- X is hydrogen or N(CH3)2,
- Y is CH2 or C═O,
- R is hydrogen or halogen,
- or a pharmaceutically acceptable salt thereof.
A method of preventing seizures, reducing the frequency of seizures, or reducing the severity of seizures, wherein the method comprises administering to an animal a compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- X is hydrogen or N(CH3)2;
- Y is CH2 or C═O;
- and
- R is hydrogen or halogen.
Dependencies are inferred from the claim text.