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US 12,421,185 B2Granted
Compositions and methods for treating cancer
AssigneeCedars-Sinai Medical Center
InventorsMichael Freeman, Mirja Rotinen, Ramachandran Murali, Sungyong You
Life of this patent
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Abstract
Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.
Claims14
A compound represented by Formula IA:
- or a pharmaceutically acceptable salt thereof;
- wherein
- Y is heteroaryl, which can be optionally substituted;
- and
- n is 1 or 2;
- or
- Y is —CH(NH2)CH2OH, —CH2CH2NHC(O)CH3, —CH2C(O)NHOH, —C(O)CH(NH2)CH2OH, —NHC(O)CH(NH2)CH2OH, piperidinecarboxamide, piperidone, or N-hydroxybenzamide;
- and
- n is 1, 2, or 3.
6 more elements
A compound represented by Formula IB:
- or a pharmaceutically acceptable salt thereof;
- wherein
- Y is heterocyclyl, which can be optionally substituted;
- and
- n is 2 or 3;
- or
- Y is —CH2CH2NHC(O)CH3, —CH2C(O)NHOH, —C(O)CH(NH2)CH2OH, —NHC(O)CH(NH2)CH2OH, piperidinecarboxamide, piperidone, or N-hydroxybenzamide;
- and
- n is 2 or 3.
6 more elements
A compound represented by Formula IA:
- or a pharmaceutically acceptable salt thereof;
- wherein
- Y is —CH(NH2)CH2OH, —CH2CH2NHC(O)CH3, —CH2C(O)NHOH, —C(O)CH(NH2)CH2OH, —NHC(O)CH(NH2)CH2OH, piperidinecarboxamide, piperidone, or N-hydroxybenzamide;
- and
- n is 1, 2, or 3.
2 more elements
Dependencies are inferred from the claim text.