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US 12,419,990 B2Granted
Ophthalmic viscoelastic compositions
AssigneeBausch & Lomb Incorporated
InventorsKimberly Anne Millard, Madhu Ayyagari, Erning Xia, Bill Reindel
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Abstract
A viscoelastic composition is disclosed which comprises (a) tris(hydroxymethyl)aminomethane or a salt thereof; (b) a phosphate buffer agent; and (c) a viscoelastic agent having an average molecular weight of about 100 to about 5,000,000.
Claims29
A viscoelastic composition comprising:
- (a) about 0.001 to about 1 wt. %, based on the total weight of the viscoelastic composition, of tris(hydroxymethyl)aminomethane or a salt thereof;
- (b) about 0.001 to about 2 wt. %, based on the total weight of the viscoelastic composition, of a phosphate buffer agent, wherein the phosphate buffer agent comprises one or more of sodium hydrogen phosphate monobasic, sodium hydrogen phosphate dibasic, potassium hydrogen phosphate monobasic and potassium hydrogen phosphate dibasic;
- and
- (c) about 0.001 to about 10 wt. %, based on the total weight of the viscoelastic composition, of a viscoelastic agent having an average molecular weight of about 500,000 to about 5,000,000;
- wherein the viscoelastic composition is one of a dispersive viscoelastic composition and a cohesive viscoelastic composition, the dispersive viscoelastic composition having a low-shear viscosity from about 20,000 centipoise (cPs) to about 80,000 cPs, and the cohesive viscoelastic composition having a low-shear viscosity of from about 75,000 cPs to about 475,000 cPs;
- and
- wherein the viscoelastic composition has a pH of about 6 to 7.8.
4 more elements
A viscoelastic composition comprising:
- (a) about 0.1 to about 0.5 wt. %, based on the total weight of the viscoelastic composition, of tris(hydroxymethyl)aminomethane or a salt thereof;
- (b) about 0.1 to about 0.5 wt. %, based on the total weight of the viscoelastic composition, of a phosphate buffer agent, wherein the phosphate buffer agent comprises one or more of sodium hydrogen phosphate monobasic, sodium hydrogen phosphate dibasic, potassium hydrogen phosphate monobasic and potassium hydrogen phosphate dibasic;
- and
- (c) about 0.5 to about 5 wt. %, based on the total weight of the viscoelastic composition, of hyaluronic acid or a salt thereof having an average molecular weight of about 500,000 to about 1,900,000;
- wherein the viscoelastic composition is a dispersive viscoelastic composition having a low-shear viscosity from about 20,000 centipoise (cPs) to about 80,000 cPs;
- and
- wherein the viscoelastic composition maintains a pH of about 6 to 7.8 at storage temperature and at room temperature during ocular surgery, the storage temperature being a temperature lower than room temperature.
4 more elements
A viscoelastic composition comprising:
- (a) about 0.1 to about 0.5 wt. %, based on the total weight of the viscoelastic composition, of tris(hydroxymethyl)aminomethane or a salt thereof;
- (b) about 0.1 to about 0.5 wt. %, based on the total weight of the viscoelastic composition, of a phosphate buffer agent, wherein the phosphate buffer agent comprises one or more of sodium hydrogen phosphate monobasic, sodium hydrogen phosphate dibasic, potassium hydrogen phosphate monobasic and potassium hydrogen phosphate dibasic;
- and
- (c) about 0.5 to about 5 wt. %, based on the total weight of the viscoelastic composition, of hyaluronic acid or a salt thereof having an average molecular weight of about 2,000,000 to about 5,000,000;
- wherein the viscoelastic composition is a cohesive viscoelastic composition having a low-shear viscosity of from about 75,000 centipoise (cPs) to about 475,000 cPs;
- and
- wherein the viscoelastic composition maintains a pH of about 6 to 7.8 at storage temperature and at room temperature during ocular surgery, the storage temperature being a temperature lower than room temperature.
4 more elements
Dependencies are inferred from the claim text.