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US 12,419,975 B2Granted
Liquid vehicle for enterography examination
OwnerPeter Quaglianoinventor
Life of this patent
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Abstract
The liquid vehicles can be used to create dilute solutions of water-soluble pharmaceutical or non-pharmaceutical oral contrast agents. The liquid vehicles are formulated to provide desired osmolalities, viscosities, pH, and taste masking capabilities to match the particular intentions of the user and to complement the inherent differences in the various oral contrast agents. The liquid vehicles comprise an aqueous medium, an osmotic agent to adjust osmolality, a buffering agent, a viscosity agent, and sweeteners and flavoring agents to improve palatability.
Claims33
A liquid vehicle for enterography examination comprising:
- a solution for oral administration prior to the enterography examination by computed tomography imaging or magnetic resonance imaging, wherein the solution comprises (a) water;
- (b) about 0 gram/liter to about 8 grams/liter mannitol;
- (c) about 12 grams/liter to about 22 grams/liter sorbitol;
- (d) a palatability agent including one or more of a sweetener, flavor or bitterness blocker, and (e) one or more buffering agents that maintain the pH of the solution within the range of about 2.5 to about 7, wherein the solution defines a viscosity within the range of about 1 to about 200 cps, the solution does not comprise a barium-sulfate contrast agent, oral administration of the solution distends a small bowel lumen, and the solution retains water in the small bowel lumen during the enterography examination sufficient to maintain a distention of the small bowel lumen to obtain visualization and differentiation of the small bowel lumen from adjacent structures by the computed tomography or magnetic resonance imaging.
1 more element
Dependencies are inferred from the claim text.