DNABII vaccines and antibodies with enhanced activity
AssigneeResearch Institute At Nationwide Children's Hospital
InventorsLauren O. Bakaletz, Steven D. Goodman
Life of this patent
Estimating the term…
Abstract
The disclosure provides methods and compositions that are useful to lessen and/or cure bacterial biofilms and treat diseases or disorders associated with biofilms using one or more novel polypeptide vaccines, antibodies, antibody fragments and compositions. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system and/or traditional antibiotics.
Claims54
A polynucleotide encoding a polypeptide comprising the polypeptide of SEQ ID NO:
- 50.
A polynucleotide encoding a polypeptide comprising the peptide of SEQ ID NO:
- 12 (FLEEIRLSLESGQDVKLSGF) and the peptide of SEQ ID NO:
- 15 (TLSAKEIENMVKDILEFISQ).
A polynucleotide encoding a polypeptide comprising the peptide of SEQ ID NO:
- 13 (RPGRNPKTGDVVPVSARRVV) and the peptide of SEQ ID NO:
- 17 (FSLHHRQPRLGRNPKTGDSV).
A polynucleotide encoding a polypeptide consisting of the polypeptide of SEQ ID NO:
- 50.
Dependencies are inferred from the claim text.