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US 12,419,934 B2Granted
Molecular signature of cancer
AssigneeWake Forest University Health Sciences
InventorsWaldemar Debinski, Jill Wykosky, Denise Mazess Herpai
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Abstract
The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
Claims9
A composition comprising, together in a pharmaceutically acceptable carrier:
- a first compound that specifically binds to an Eph receptor in a subject in a treatment effective amount, wherein said first compound comprises active ephrin A1 in monomeric form, and wherein said first compound is coupled to a first therapeutic agent, and
- a second compound that specifically binds to an IL-13 receptor (IL-13R) in a subject in a treatment effective amount, wherein said second compound comprises IL-13 or an anti-IL-13Rα2 antibody or peptide, and wherein said second compound is coupled to a second therapeutic agent.
Dependencies are inferred from the claim text.