Thrombosomes as an antiplatelet agent reversal agent
AssigneeCellphire, Inc.
InventorsKeith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
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Abstract
In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.
Claims20
A method of treating bleeding in a human subject, the method comprising
- administering to the human subject in need thereof, an effective amount of a rehydrated composition comprising freeze-dried platelet derivatives (FDPDs) and an incubating agent comprising one or more saccharides, one or more salts, and a buffer,
- wherein the one or more saccharides comprise trehalose in the range of 10 mM to 500 mM,
- wherein the FDPDs have less than 10% crosslinking of platelet membranes via proteins and/or lipids present on the membranes, and 50% to 99% of the FDPDs have a diameter in the range of 0.3 μm to 5.0 μm,
- wherein the human subject is being treated with aspirin and an antiplatelet agent selected from the group consisting of cangrelor, ticagrelor, prasugrel, abciximab, terutroban, picotamide, elinogrel, vorapaxar, atopaxar, cilostazol, epoprostenol, dipyridamole, treprostinil sodium, sarpogrelate, clopidogrel, eptifibatide, tirofiban, and ticlopidine, such that treatment with aspirin and the antiplatelet agent is continued before and after the administering without stopping the treatment,
- wherein the administering comprises administering parenterally or topically, and
- wherein the effective amount of the composition is at least 5.0×109 FDPDs/kg of the human subject.
Dependencies are inferred from the claim text.