Methods and compositions for the treatment of amyloid-related disorders
AssigneeYale University
InventorsStephen M. Strittmatter, Erik Christian Gunther, Levi M. Smith
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Abstract
The disclosure provides polymeric compounds that inhibit binding of an amyloid-β-oligomer to cellular prion protein, methods for identifying such compounds, and their therapeutic use. In particular, the present disclosure provides a collection of anionic polymers and methods of using these compounds to treat amyloid-related disorders, e.g., Alzheimer's disease.
Claims19
A method of treating an amyloid-related disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an anionic polymer, or a pharmaceutically acceptable salt thereof, wherein the anionic polymer comprises poly (4-styrenesulfonic acid-co-maleic acid), or the sodium salt thereof.
Dependencies are inferred from the claim text.