Methods of treating elevated plasma cholesterol
AssigneesInstitut de Cardiologie de Montreal, Affina Biotechnologies, Inc.
InventorsAlan Berezov, Alexander Vinitsky, Steve Poirier, Gaétan Mayer
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Abstract
The present invention relates to compounds of Table 1, which are encompassed by Formula I and/or Formula II, Ill, IV, V, or VI, and pharmaceutically acceptable salts, solvates or compositions thereof. Compounds of Table 1 are PCSK9 interacting small molecules that modulate PCSK9 activity and significantly increase low density lipoprotein receptor expression and activity, lower total circulating cholesterol and are useful for treating and delaying the onset of diseases that are associated with elevated cholesterol.
Claims5
A method of lowering cholesterol levels in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound having the structure of compound 26:
A method of binding, modulating PCSK9 activity, and inducing expression of low density lipoprotein receptor (LDLR) in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound having the structure of compound 26:
A method of treating hypercholesterolemia in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound having the structure of compound 26:
Dependencies are inferred from the claim text.