Compositions and methods for treating iron overload
AssigneeBrigham Young University
InventorRichard K. Watt
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compositions and methods for treating iron overload. In particular, the methods for treating iron overload include administering to a patient an HIV protease inhibitor and an iron chelator. Iron overload may occur in patients diagnosed with anemia from inflammation or from chronic disease including hemochromatosis, sickle cell disease, thalassemia, sideroblastic anemia, an enzyme deficiency, pre-operative anemia, a cardiovascular disease, atransferrinemia, or aceruloplasminemia.
Claims11
A method of treating iron overload in a patient having β-thalassemia major, comprising administering to the patient a therapeutically effective amount of nelfinavir to inhibit hepcidin formation by inhibiting furin leading to iron release from iron overloaded organs deferiprone to remove serum iron.
Dependencies are inferred from the claim text.