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US 12,419,876 B2Granted
Treatment of hearing loss by inhibition of casein kinase 1
AssigneeMassachusetts Eye and Ear Infirmary
InventorsAlbert Edge, Yenfu Cheng
Life of this patent
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Abstract
Methods for treating hearing loss that include administering an inhibitor, e.g., a small molecule inhibitor, of casein kinase 1, preferably in combination with a treatment that stimulates Atoh1 gene expression, e.g., a gamma-secretase inhibitor, an Atoh1 stimulatory compound, or a GSK-3-beta inhibitor.
Claims14
A method of treating a subject who has or is at risk of developing hearing loss or vestibular dysfunction, the method comprising:
- identifying a subject who has experienced, or is at risk for developing, hearing loss or vestibular dysfunction;
- and
- administering to the subject one or more nucleic acids that target casein kinase 1 (CK1) epsilon and/or CK1 delta, and one or more compounds that stimulate Atoh1 gene expression.
Dependencies are inferred from the claim text.