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US 12,419,839 B2Granted
Methods and compositions for targeted delivery of protein fragments
AssigneeSignablok, Inc.
InventorAlexander Sigalov
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Abstract
The present invention is related to the field of targeted drug delivery. In particular, the particles and compositions described herein are used to deliver drugs to treat the diseases and conditions of interest. These particles and compositions include, but are not limited to, the lipopeptide complexes that mimic human high-density lipoproteins but contain apolipoprotein fragments or combination thereof.
Claims40
A composition comprising a reconstituted lipoprotein nanoparticle comprising:
- i a plurality of phospholipids;
- ii) at least one apolipoprotein fragment comprising a modification, wherein said modification comprises one or two sulfoxidized methionine residues and not a modified tyrosine residue, wherein only protein constituents are oxidized;
- and
- iii) at least one therapeutic agent attached to said nanoparticle.
1 more element
A composition, comprising a reconstituted lipoprotein nanoparticle comprising:
- i) a triglyceride-cholesterol ester core surrounded by a plurality of phospholipids;
- ii) at least one apolipoprotein fragment comprising a modification, wherein said modification comprises one or two sulfoxidized methionine residues and not a modified tyrosine residue, wherein only protein constituents are oxidized;
- and
- iii) at least one therapeutic agent attached to said nanoparticle.
1 more element
Dependencies are inferred from the claim text.