Mediation of in vivo analyte signal degradation
AssigneeSenseonics, Incorporated
InventorsJoon Chatterjee, Sanat Mohanty, Philip Huffstetler
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Abstract
A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds having dithio-, thio- or mercapto-containing moieties that reduce degradation of the analyte indicator.
Claims28
A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:
- a sensor housing;
- an analyte indicator covering at least a portion of the sensor housing;
- and
- one or more compounds having dithio-, thio- or mercapto-containing moieties, wherein the one or more compounds having dithio-, thio-, or mercapto-containing moieties reduce a degradation rate of the analyte indicator and are selected from:
- a) 3,3′-Dithiodipropionic acid, 4,4′-Dithiodibutyric acid, Dithiodiglycolic acid, 2-Hydroxyethyl disulfide, S,S′-Methylenebis (3-Mercaptopropionic acid), 3-Mercaptopropionic acid, 6,6′-Dithiodinicotinic acid, Lipoic acid, 1,2-Dithiolane-3-pentanoic acid, Lipoic acid, reduced, Thioctic acid, ditridecyl thiodipropionate, distearyl thiodipropionate, dimyristyl thiodipropionate, Dilauryl thiodipropionate, 3,3′-Thiodipropionic acid, 3,3′-Thiodipropionic acid, Didodecyl 3,3′-thiodipropionate, 2,2′-Thiodiacetic acid, 4,4′-Thiodiphenol, Thiodipropionic acid dilauryl ester, 3,3′-Thiodipropanol, Glutathione, 2,2′-(Ethylenedithio) diacetic acid, Ergothioneine, Methionine, 3-Mercaptopropane-1,2-diol, dithionate salts, thioglycolate salts, thiomalate salts, Lipoyllysine, and any combination thereof;
- b) cysteine and compounds represented by Formula IV
- or a salt, ester, hydrate, solvate, or amide thereof;
- or
- c) both a) and b).
A method of fabricating a sensor for measurement of an analyte in a medium within a living animal, the method comprising:
- inserting the sensor into a composition for an amount of time sufficient to effect soaking of the composition into the analyte indicator, wherein the sensor includes a sensor housing and an analyte indicator that covers at least a portion of the sensor housing, and the composition comprises one or more compounds having dithio-, thio- or mercapto-containing moieties;
- and
- removing the sensor from the composition,
- wherein the one or more compounds having dithio-, thio- or mercapto-containing moieties reduce a degradation rate of the analyte indicator and are selected from:
- a) 3,3′-Dithiodipropionic acid, 4,4′-Dithiodibutyric acid, Dithiodiglycolic acid, 2-Hydroxyethyl disulfide, S,S′-Methylenebis (3-Mercaptopropionic acid), 3-Mercaptopropionic acid, 6,6′-Dithiodinicotinic acid, Lipoic acid, 1,2-Dithiolane-3-pentanoic acid, Lipoic acid, reduced, Thioctic acid, ditridecyl thiodipropionate, distearyl thiodipropionate, dimyristyl thiodipropionate, Dilauryl thiodipropionate, 3,3′-Thiodipropionic acid, 3,3′-Thiodipropionic acid, Didodecyl 3,3′-thiodipropionate, 2,2′-Thiodiacetic acid, 4,4′-Thiodiphenol, Thiodipropionic acid dilauryl ester, 3,3′-Thiodipropanol, Glutathione, 2,2′-(Ethylenedithio) diacetic acid, Ergothioneine, Methionine, 3-Mercaptopropane-1,2-dio, dithionate salts, thioglycolate salts, thiomalate salts, Lipoyllysine, and any combination thereof;
- b) cysteine and compounds represented by Formula IV
- or a salt, ester, hydrate, solvate, or amide thereof;
- or
- c) both a) and b).
Dependencies are inferred from the claim text.