Biomarkers for irritable bowel syndrome
OwnerKevin Whelan, Bridgette Wilson +3inventors
InventorsKevin Whelan, Bridgette Wilson, Megan Rossi, Chris Probert, Rachael Slater
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Abstract
The present invention relates to a method of determining the probability that an individual has irritable bowel syndrome and whether the individual will respond to dietary intervention. The present invention also provides a method of determining the probability that an individual with irritable bowel syndrome will respond to dietary intervention. There is also provided the use of a compound as defined herein as a biomarker.
Claims20
A method of determining the probability that an individual has irritable bowel syndrome and whether the individual will respond to dietary intervention, the method comprising the steps of:
- i) analysing a stool sample collected from said individual to determine whether a cyclohexane carboxylic acid compound is present;
- and
- ii) if a cyclohexane carboxylic acid compound is present in step i), determining the amount of the cyclohexane carboxylic acid compound that is present and comparing the amount detected with a control value;
- wherein the presence of an increased amount of the cyclohexane carboxylic acid compound compared to the control value is indicative of an increased probability that the individual has irritable bowel syndrome and of the probability that the individual will respond to dietary intervention;
- and wherein the cyclohexane carboxylic acid compound is one or more of a cyclohexane carboxylic acid and/or a cyclohexane carboxylic acid ester.
A method of determining the probability that an individual with irritable bowel syndrome will respond to dietary intervention, the method comprising the steps of:
- i) analysing a stool sample collected from said individual to determine whether a cyclohexane carboxylic acid compound is present;
- and
- ii) if a cyclohexane carboxylic acid compound is present in step i), determining the amount of the cyclohexane carboxylic acid compound that is present and comparing the amount detected with a control value;
- wherein the presence of an increased amount of the cyclohexane carboxylic acid compound compared to the control value is indicative of an increased probability that the individual will respond to dietary intervention;
- and wherein the cyclohexane carboxylic acid compound is one or more of a cyclohexane carboxylic acid and/or a cyclohexane carboxylic acid ester.
Dependencies are inferred from the claim text.