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US 12,415,862 B2Granted
Methods and compositions
AssigneeAlligator Bioscience AB
InventorsPeter Ellmark, Per Norlen, Karin Hagerbrand
Life of this patent
Estimating the term…
Abstract
The present invention provides polypeptides capable of targeting antigens, such as neoantigens, to particular immune cells, and associated therapeutic methods. In particular embodiments, the polypeptides are antibodies or antibody-based polypeptides.
Claims20
A complex comprising a polypeptide and a tagged antigen,
- wherein the polypeptide comprises at least one immune cell binding domain and at least one tag binding domain,
- wherein the at least one immune cell binding domain specifically binds to an immune cell target, and
- wherein the at least one tag binding domain specifically binds to a tag, and
- wherein the tagged antigen comprises the tag to which the tag binding domain of the polypeptide binds.
1 more element
A polypeptide comprising at least one immune cell binding domain and at least one tag binding domain,
- wherein the at least one immune cell binding domain is capable of specifically binding to an immune cell target;
- and
- wherein the at least one tag binding domain is capable of specifically binding to a tag, optionally a peptide tag, wherein the peptide tag is not derived from tetanus toxin.
A complex formed by contacting a polypeptide with a tagged antigen in vitro,
- wherein the polypeptide comprises at least one immune cell binding domain and at least one tag binding domain,
- wherein the at least one immune cell binding domain specifically binds to an immune cell target, and
- wherein the at least one tag binding domain specifically binds to a tag, and
- wherein the tagged antigen comprises the tag to which the tag binding domain of the polypeptide binds, optionally wherein the tag is a peptide tag.
1 more element
Dependencies are inferred from the claim text.