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US 12,415,829 B2Granted
Progesterone phosphate analogs and uses related thereto
AssigneeEmory University
InventorsDavid Brian Guthrie, Mark Andrew Lockwood, Michael G. Natchus, Dennis C. Liotta, Donald G. Stein, Iqbal Sayeed
Life of this patent
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Abstract
This disclosure relates to progesterone phosphate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.
Claims20
A compound of Formula IA:
- or esters, or salts thereof, wherein:
- Z is O;
- R1 is alkyl and R2 is hydrogen or alkyl, or R1 and R2 form a carbocyclic ring;
- R3 is hydrogen, a sodium ion, or a quaternary ammonium ion;
- and
- R3′ is sodium or a quaternary ammonium.
3 more elements
Dependencies are inferred from the claim text.