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US 12,415,822 B2Granted
Small molecule inhibitors selective for polo-like kinase protein
AssigneeUniversity of South Carolina
InventorsCampbell McInnes, Sandra Navonne Craig
Life of this patent
Estimating the term…
Abstract
Disclosed are small molecule PLK inhibitors that can target the polo box domain (PBD). Inhibitors can have an atomic mass of about 1000 Da or less and a general structure of For instance, the inhibitors can include an alkyl benzamido benzoic acid core structure.
Claims13
A method for inhibiting Polo-like Kinase proteins, the method comprising:
- providing a small molecule PLK inhibitor to a medium containing one or more Polo-like Kinase proteins, wherein the small molecule PLK inhibitor has the following structure:
- wherein
- R1 comprises an alkyl, —O-alkyl, —S-alkyl, or —NH-alkyl, and optionally includes a terminal aryl;
- R7 is selected from:
1 more element
A method for inhibiting Polo-like Kinase proteins, the method comprising:
- providing a small molecule PLK inhibitor to a medium containing one or more Polo-like Kinase proteins, wherein the small molecule PLK inhibitor has the structure of one or more of:
Dependencies are inferred from the claim text.