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US 12,415,771 B2Granted
Compounds for the treatment of neuromuscular disorders
AssigneeNmd Pharma A/S
InventorsLars J. S. Knutsen, Nicholas Kelly, Martin Brandhøj Skov, Anders Riisager, Neerja Saraswat
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein can inhibit the CIC-1 ion channel.
Claims19
A compound of Formula (I):
- wherein:
- R1 is selected from the group consisting of C1-2 alkyl, C2 alkenyl, C2 alkynyl, CN, CF3, NO2, F, Cl, Br, and I;
- R2 is selected from the group consisting of C1-5 alkyl optionally be substituted with one or more, identical or different, substituents R6, C2-5 alkenyl optionally be substituted with one or more, identical or different, substituents R6, C2-5 alkynyl optionally be substituted with one or more, identical or different, substituents R6, C3-5 cycloalkyl optionally substituted with one or more, identical or different, substituents R6, phenyl optionally substituted with one or more, identical or different, substituents R9, and 5-6 membered aromatic heterocycle optionally substituted with one or more, identical or different, substituents R7;
- R3 is selected from the group consisting of deuterium, Cl and F;
- R4 is selected from the group consisting of H, deuterium, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, and C3-5 cycloalkyl, each of which may be optionally substituted with one or more, identical or different, substituents R7;
- R5 is selected from the group consisting of H, C1-5 alkyl optionally substituted with one or more, identical or different, substituents R8, C2-5 alkenyl optionally substituted with one or more, identical or different, substituents R8, C2-5 alkynyl optionally substituted with one or more, identical or different, substituents R8, C3-6 cycloalkyl optionally substituted with one or more, identical or different, substituents R8, phenyl optionally substituted with one or more, identical or different, substituents R9, and benzyl optionally substituted with one or more, identical or different, substituents R9;
- R6 is independently selected from the group consisting of deuterium, F, —CN, —O—C1-5 alkyl, —O—C3-5 cycloalkyl, —S—C1-5 alkyl, and —S—C3-5 cycloalkyl, wherein the —O—C1-5 alkyl, —O—C3-5 cycloalkyl, —S—C1-5 alkyl, and —S—C3-5 cycloalkyl may optionally be substituted with one or more, identical or different, substituents R8;
- R7 is independently selected from the group consisting deuterium, F, C1, —CN, C3-5 cycloalkyl, —O—C1-5 alkyl, —O—C3-5 cycloalkyl, —S—C1-5 alkyl, and —S—C3-5 cycloalkyl, wherein the C3-5 cycloalkyl, —O—C1-5 alkyl, —O—C3-5 cycloalkyl, —S—C1-5 alkyl, and —S—C3-5 cycloalkyl may optionally be substituted with one or more, identical or different, substituents R8;
- R8 is independently selected from the group consisting of deuterium and F;
- R9 is independently selected from the group consisting of deuterium, methoxy, nitro, cyano, Cl, Br, I, and F;
- X is a bond or selected from the group consisting of —O—, —S—, —CH2—, —CHR6—, and —C(R6)2—;
- and
- n is an integer 0, 1, 2, or 3;
- or a pharmaceutically acceptable salt, hydrate, polymorph, tautomer, or solvate thereof.
11 more elements
Dependencies are inferred from the claim text.