# US 12,415,075 B2 · Integrated sleep apnea and at least one of cardiac monitoring and cardiac therapy

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- Number: US 12,415,075 B2
- Document ID: US12415075B2
- Status: Granted
- Kind: B2
- Application number: 18/068,932
- Filed: 2022-12-20
- Published: 2023-08-03
- Granted: 2025-09-16
- Earliest claimed: 2022-02-03
- Assignees: Medtronic, Inc.
- Applicants: Medtronic, Inc.
- Inventors: Avram Scheiner; Randal C. Schulhauser; Becky L. Dolan
- Web page: https://patentgrep.com/patent/US12415075B2

## CPC

- A61N 1/36078: {Inducing or controlling sleep or relaxation (non-implantable stimulator A61M21/00)}
- A61N 1/3611: {Respiration control (stimulating respiratory organs A61N1/3601)}
- A61B 5/0205: Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
- A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)}
- A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)}
- A61N 1/36114: {Cardiac control, e.g. by vagal stimulation (stimulating the heart A61N1/362)}
- A61N 1/36139: {with automatic adjustment}
- A61N 1/3615: {Intensity}
- A61N 1/36167: {Timing, e.g. stimulation onset}
- A61N 1/3622: {comprising two or more electrodes co-operating with different heart regions}
- A61N 1/36507: {controlled by gradient or slope of the heart potential}
- A61N 1/36514: {controlled by a physiological quantity other than heart potential, e.g. blood pressure (controlled by two or more physical parameters A61N1/36585)}
- A61N 1/36585: {controlled by two or more physical parameters}
- A61N 1/36592: {controlled by the heart rate variability}
- A61N 1/37235: {Aspects of the external programmer}
- A61N 1/36117: {for treating hypertension}
- A61N 1/3624: {occurring in the atrium, i.e. atrial tachycardia}
- A61N 1/36535: {controlled by body position or posture}
- A61N 1/36542: {controlled by body motion, e.g. acceleration}
- A61N 1/3655: {controlled by body or blood temperature}
- A61N 1/36564: {controlled by blood pressure}
- A61N 1/36571: {controlled by blood flow rate, e.g. blood velocity or cardiac output}
- A61N 1/3702: {Physiological parameters (A61N1/365 takes precedence; evoked response A61N1/371)}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

An implantable medical device (IMD) includes therapy delivery circuitry, sensing circuitry, and processing circuitry. The processing circuitry is configured to determine one or more sleep apnea therapy parameters, control the therapy delivery circuitry to deliver sleep apnea therapy via a first set of electrodes implantable within the patient in accordance with the one or more sleep apnea therapy parameters, and at least one of: (1) monitor a cardiac signal sensed with the sensing circuitry, or (2) determine one or more cardiac therapy parameters, and control the therapy delivery circuitry to deliver cardiac therapy via a second set of electrodes implantable within the patient in accordance with the one or more cardiac therapy parameters.

## Claims

### Claim 1

An implantable medical device (IMD), the IMD comprising:
therapy delivery circuitry;
sensing circuitry; and
processing circuitry configured to:
determine one or more sleep apnea therapy parameters;
control the therapy delivery circuitry to deliver sleep apnea therapy via a first set of electrodes implantable within a patient in accordance with the one or more sleep apnea therapy parameters;
determine a condition associated with the sleep apnea based on sensing via the sensing circuitry, wherein the condition comprises a low tone of a tongue of the patient or an apneic episode of the patient;
determine one or more cardiac therapy parameters in response to determination of the condition; and
control the therapy delivery circuitry to deliver cardiac therapy via a second set of electrodes implantable within the patient in accordance with the one or more cardiac therapy parameters.

### Claim 2 (depends on 1)

The IMD of claim 1, wherein the cardiac therapy includes one or more of defibrillation therapy, cardiac resynchronization therapy (CRT), bradycardia therapy, and arrhythmia therapy.

### Claim 3 (depends on 1)

The IMD of claim 1, wherein the sleep apnea therapy includes one or more of obstructive sleep apnea (OSA) therapy, central sleep apnea (CSA) therapy, and mixed apnea therapy.

### Claim 4 (depends on 1)

The IMD of claim 1, wherein the therapy delivery circuitry is configured to deliver the cardiac therapy via one or more leads that are configured to be implanted extravascularly and the second set of electrodes that are configured to be implanted extravascularly.

### Claim 5 (depends on 1)

The IMD of claim 1, wherein the therapy delivery circuitry is configured to deliver the sleep apnea therapy to at least one of:
motor points of one or both hypoglossal nerves; and
a phrenic nerve.

### Claim 6 (depends on 1)

The IMD of claim 1, wherein the processing circuitry is configured to determine the sleep apnea therapy parameters based on monitored cardiac signal.

### Claim 7 (depends on 1)

The IMD of claim 1, wherein the therapy delivery circuitry includes one of:
common circuitry to deliver the cardiac therapy and the sleep apnea therapy; or
cardiac therapy delivery circuitry configured to deliver the cardiac therapy and sleep apnea therapy delivery circuitry configured to deliver the sleep apnea therapy.

### Claim 8

A method of controlling therapy, the method comprising:
determining one or more sleep apnea therapy parameters;
controlling a therapy delivery circuitry to deliver sleep apnea therapy via a first set of electrodes implantable within a patient in accordance with the one or more sleep apnea therapy parameters;
determining a condition associated with the sleep apnea based on sensing via sensing circuitry, wherein the condition comprises a low tone of a tongue of the patient or an apneic episode of the patient;
determining one or more cardiac therapy parameters in response to determination of the condition; and
controlling the therapy delivery circuitry to deliver cardiac therapy via a second set of electrodes implantable within the patient in accordance with the one or more cardiac therapy parameters.

### Claim 9 (depends on 8)

The method of claim 8, wherein the cardiac therapy includes one or more of defibrillation therapy, cardiac resynchronization therapy (CRT), bradycardia therapy, and arrhythmia therapy.

### Claim 10 (depends on 8)

The method of claim 8, wherein the sleep apnea therapy includes one or more of obstructive sleep apnea (OSA) therapy, central sleep apnea (CSA) therapy, and mixed apnea therapy.

### Claim 11 (depends on 8)

The method of claim 8, wherein controlling the therapy delivery circuitry to deliver the cardiac therapy comprises causing the therapy delivery circuitry to deliver the cardiac therapy via one or more leads that are configured to be implanted extravascularly and the second set of electrodes that are configured to be implanted extravascularly.

### Claim 12 (depends on 8)

The method of claim 8, wherein controlling the therapy delivery circuitry to deliver the sleep apnea therapy comprises causing the therapy delivery circuitry to deliver the sleep apnea therapy to at least one of:
motor points of one or both hypoglossal nerves; and
a phrenic nerve.

### Claim 13 (depends on 8)

The method of claim 8, wherein determining the sleep apnea therapy parameters comprises determining the sleep apnea therapy parameters based on monitored cardiac signal.

### Claim 14

A non-transitory computer-readable storage medium storing instructions thereon that when executed cause one or more processors to:
determine one or more sleep apnea therapy parameters;
control a therapy delivery circuitry to deliver sleep apnea therapy via a first set of electrodes implantable within a patient in accordance with the one or more sleep apnea therapy parameters;
determining a condition associated with the sleep apnea based on sensing via the sensing circuitry, wherein the condition comprises a low tone of a tongue of the patient or an apneic episode of the patient;
determine one or more cardiac therapy parameters in response to determination of the condition; and
control the therapy delivery circuitry to deliver cardiac therapy via a second set of electrodes implantable within the patient in accordance with the one or more cardiac therapy parameters.