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US 12,415,025 B2Granted
Physiologic cardiovascular pH balanced counter current electrolyte transfer and fluid removal system
AssigneeNephratech LLC
InventorsRichard Denison, Mary Claire McGarry
Life of this patent
Estimating the term…
Abstract
Certain embodiments of the invention are directed to methods of adjusting the concentration of one or more electrolytes in a patient's blood using a counter current electrolyte solution.
Claims32
A method of establishing physiological conditions in a patient's whole blood while the patient is connected to a cardiopulmonary bypass machine including a blood pump that produces a blood pressure of the patient's whole blood and the patient's whole blood to flow within the cardiopulmonary bypass machine to maintain the physiological conditions of the patient's circulation, the method comprising:
- (a) providing a self-contained system having a filter, wherein the filter comprises a first filter chamber and a second filter chamber separated by a semi-permeable barrier, the first filter chamber connected to blood flow inlet tubing and blood flow outlet tubing and the second filter chamber connected to wash solution inlet tubing and wash solution outlet tubing;
- (b) connecting the blood flow inlet tubing of the self-contained system to the cardiopulmonary bypass machine;
- (c) connecting the blood flow outlet tubing of the self-contained system to the cardiopulmonary bypass machine;
- (d) flowing the patient's whole blood through the first filter chamber and the blood flow inlet tubing under the blood pressure of the patient's whole blood created by the cardiopulmonary bypass machine, the first filter chamber being shunted under the blood pressure of the patient's blood from the cardiopulmonary bypass machine, the patient's whole blood flowing in a first direction through the first filter chamber, through the blood flow outlet tubing and into the cardiopulmonary bypass machine;
- (e) flowing a first wash solution through the second filter chamber and wash solution inlet and outlet tubing in a second direction of flow, the first direction being generally opposite the second direction, a wash solution input pump controlling a rate of flow of the first wash solution into the second filter chamber and an effluent pump controlling a rate of flow of effluent out of the second filter chamber;
- (f) controlling the rate of flow of the first wash solution and the rate of flow of the effluent based on a pressure in the second filter chamber;
- and
- (g) normalizing a cardiopulmonary circuit of the cardiopulmonary bypass machine before connecting the cardiopulmonary bypass machine to the patient and prior to step (d) by normalizing electrolytes in blood in the cardiopulmonary bypass machine.
5 more elements
A method of establishing physiological conditions in a patient's blood while the patient is connected to a cardiopulmonary bypass machine, including a cardiopulmonary bypass heart/lung machine, that produces a blood pressure of the patient's blood, the method comprising:
- (a) providing a self-contained system having a filter configured for connection to the cardiopulmonary bypass machine and a controller, the filter includes a first filter chamber and a second filter chamber separated by a semi-permeable barrier, the first filter chamber connected to blood flow inlet tubing and blood flow outlet tubing and the second filter chamber connected to wash solution inlet tubing and wash solution outlet tubing;
- (b) connecting the blood flow inlet tubing to the cardiopulmonary bypass machine at a medical facility;
- (c) connecting the blood flow outlet tubing to the cardiopulmonary bypass machine at the medical facility;
- (d) flowing the patient's blood through the first filter chamber and the blood flow inlet and outlet tubing, the patient's blood flowing in a first direction through the first filter chamber;
- (e) flowing a first wash solution through the second filter chamber and wash solution inlet and outlet tubing in a second direction of flow, the first direction being generally opposite the second direction, a wash solution input pump controlling a rate of flow of the first wash solution into the second filter chamber and an effluent pump controlling a rate of flow of effluent out of the second filter chamber;
- (f) controlling the rate of flow of the first wash solution and the rate of flow of the effluent based on a pressure in the second filter chamber;
- (g) normalizing a cardiopulmonary circuit of the cardiopulmonary bypass machine before connecting the cardiopulmonary bypass machine to the patient and prior to step (d) by normalizing electrolytes in blood in the cardiopulmonary bypass machine;
- (h) operating the self-contained system with the controller in the following modes:
- (i) an electrolyte transfer mode configured to maintain a blood volume of the patient while adjusting a concentration of an electrolyte in the patient's blood;
- (ii) a fluid removal mode configured to decrease a total volume of the patient's blood;
- and
- (iii) a combination mode configured to decrease the total volume of the patient's blood while simultaneously one of adjusting the concentration of the electrolyte in the patient's blood to physiological levels and maintaining the concentration of the electrolyte in the patient's blood at physiological levels.
9 more elements
Dependencies are inferred from the claim text.