Means and methods for treating herpesvirus infection
AssigneeHelmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
InventorsWolfgang Hammerschmidt, Reinhard Zeidler, Dagmar Pich
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Abstract
The present invention provides herpesviruses, such as EBV, which lack at least one viral miRNA. Such herpesviruses lacking at least one viral miRNA are advantageously not capable of packaging their genome into the capsid, thereby producing HVLPs, which are substantially free of their herpesvirus genome or the nucleic acid molecule encoding the proteinaceous part of the HVLP and viral miRNA. Such HVLPs may be used as vaccine.
Claims19
An Epstein-Barr virus like particle (EBVLP) comprising Epstein-Barr virus (EBV) proteins, where in at least one of the three particular EBV miRNAs miR-BART17, miR-BART10, and miR-BART22 is physically absent from said EBVLP and wherein said EBVLP is substantially free of an EBV genome.
Dependencies are inferred from the claim text.