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US 12,414,969 B2Granted
Methods and compositions for reducing clostridium difficile infection
AssigneeMemorial Sloan Kettering Cancer Center
InventorsEric Pamer, Charlie Buffie, Peter McKenney
Life of this patent
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Abstract
The present invention relates to methods and compositions for reducing the risk and severity of C. difficile infection. It is based, at least in part, on the discovery that a restricted fraction of the gut microbiota, including the bacterium Clostridium scindens, contributes substantially to resistance against C. difficile infection. Without being bound by any particular theory, it is believed that this is achieved through the biosynthesis of secondary bile acids.
Claims18
A composition comprising two or more purified or isolated bacteria or spores thereof, the composition comprising:
- a first purified or isolated bacteria or spores thereof comprising Clostridium scindens;
- a second isolated or purified bacteria or spores thereof comprising Blautia hansenii or Barnesiella intestihominis;
- and
- a secondary bile acid selected from the group consisting of a deoxycholic acid, a lithocholic acid, and a combination thereof,
- wherein the two or more purified or isolated bacteria or spores thereof are in a formulation for administration to a subject, wherein at least one of the two or more purified or isolated bacteria or spores thereof is capable of converting a primary bile acid to a secondary bile acid, and
- wherein the composition comprises a capsule.
3 more elements
Dependencies are inferred from the claim text.