Hydrogel co-injection and real-time opto-electromagnetic modification device for tunable in-vivo delivery

A system for crosslinking and delivery of a hydrogel precursor within a bodily lumen, the system comprising:

• a catheter;
• flow means operably connectable to a proximal region of said catheter for delivering the hydrogel precursor into said catheter and flowing said hydrogel precursor within said catheter to a distal extrusion port within said catheter;
• a light source capable of emitting incident optical radiation suitable for crosslinking said hydrogel precursor;
• an optical fiber at least partially residing within said catheter, said optical fiber being configured to deliver the incident optical radiation emitted by said light source within said catheter such that said hydrogel precursor is illuminated by the incident optical radiation and is at least partially crosslinked by the incident optical radiation prior to and/or after being extruded through said distal extrusion port;
• wherein said catheter comprises a multilumen region residing within an outer sheath along an elongate portion of the catheter, said flow means being configured to flow the hydrogel precursor through one or more lumens of the multilumen region, and wherein said optical fiber resides, at least in part, within a selected lumen of the multilumen region;
• wherein said catheter comprises a single-lumen distal reaction chamber extending from a distal end of said multilumen region to a distal end of said catheter for partially crosslinking said hydrogel precursor within said catheter before extruding said hydrogel precursor through said distal extrusion port into the bodily lumen;
• and
• wherein a distal end of said optical fiber is longitudinally positionable within said single-lumen distal reaction chamber for controlling a volume of said hydrogel precursor that is irradiated by the incident optical radiation prior to being extruded through said distal extrusion port.