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AssigneeAsymchem Laboratories (Tianjin) Co., Ltd.
InventorsHao Hong, Gage James, Yi Xiao, Yulei Ma, Na Zhang, Xuecheng Jiao, Huiyan Mu, Yibing Cheng, Shan Cao
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Provided are a transaminase mutant and use thereof. The transaminase mutant has an amino acid sequence obtained by mutation of an amino acid sequence shown in SEQ ID NO:1, the mutation at least includes one of the following mutation site combinations: T7C+S47C, Q78C+A330C, V137C+G313C, A217C+Y252C and L295C+C328C; or the transaminase mutant has an amino acid sequence which has the mutation sites in the mutated amino acid sequence and has 80% or more identity with the mutated amino acid sequence. The transaminase mutant realizes the change of protein structure and functions, reduces the enzyme amount, increases the enantiomeric excess (ee) value of a product, and reduces the difficulty of post-processing, so that the transaminase mutant may be suitable for industrial production.
A transaminase mutant having the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.