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US 12,410,408 B2Granted
Method for hypothermic transport of biological samples
AssigneeParagonix Technologies, Inc.
InventorsDanny Macari, Matthew Whitney, Samantha Estrella, William Lucas Churchill
Life of this patent
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Abstract
A method for transporting a biological sample at hypothermic temperatures. The container can be cooled using phase change material and pump fluid through the sample. The fluid can pump through the system at a rate independent of the parameters of the biological sample. A valve can control the rate of flow of the fluid into the biological sample.
Claims18
A method for hypothermic transport of a biological sample, the method comprising:
- sealing a biological sample adapter to a vessel of a biological sample;
- placing the biological sample in a transport container;
- sealing a lid on the transport container;
- filling the transport container at least partially with preservation fluid through a fill port in the lid;
- and
- activating a pump,
- the pump configured to pump the preservation fluid through a fluid circuit from the transport container to a flow regulator valve and the biological sample adapter,
- the flow regulator valve configured to regulate a flow rate into the biological sample based on at least one biological sample parameter, wherein the flow regulator valve is configured to release fluid from the fluid circuit at a rate based on the at least one biological sample parameter, and the pump configured to operate independently of the at least one biological sample parameter and;
- wherein the at least one biological sample parameter comprises at least one of vessel resistance, biological sample temperature, or flow rate through the biological sample.
6 more elements
A method for hypothermic transport of a biological sample, the method comprising:
- pumping, using a pump, preservation fluid from a transport container to an inlet of a fluid circuit at a rate independent of vessel resistance of a biological sample;
- pumping, using the pump, the preservation fluid from the inlet to a flow regulator valve;
- regulating, using the flow regulator valve, a flow rate into the biological sample based on at least one biological sample parameter, wherein the flow regulator valve is configured to release fluid from the fluid circuit at a rate based on the at least one biological sample parameter;
- and
- pumping, using the pump, the preservation fluid from the flow regulator valve to a biological sample adapter in fluid communication with the biological sample and;
- wherein the at least one biological sample parameter comprises at least one of vessel resistance, biological sample temperature, or flow rate through the biological sample.
3 more elements
Dependencies are inferred from the claim text.